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GendAge Project Description

Mechanisms of sex-related disease are poorly understood, a fact that negatively impacts targeted and personalized prevention and treatment approaches. This gap is to be closed with the study GendAge planned here.

The study is based on an existing cohort of 1,600 women and men from the Berlin Age Study II (BASE-II) - a cohort study that has collected key variables in the areas of car-diovascular and metabolic health, socio-economic and quality of life. The first survey of this study, conducted in 2010-2014, provides an opportunity to analyze cross-sectional effects that depend on biological and socio-cultural gender (sex and gender) since, fortunately, the BASE II Initial survey has considered a variety of parameters of high relevance to the study of gender differences.

In addition, the collection of follow-up data, as part of the planned study, will enable us to conduct longitudinal analyzes to investigate the pathogenesis as well as the conditional factors and underlying mechanisms. As an important step in this direction, one of the aims of the study is to analyze, in addition to the biological sex, the role of the socio-cultural gender gender in cardiovascular risk factors and diseases. To do this, we will develop a new measure of gender that goes well beyond the traditional man-woman stereotypes, and we will fully validate this new scale and examine its utility.

GendAge thus combines the special expertise in aging research from the BASE II study with the gender research of the Institute for Gender Research in Medicine (GIM), the leading German center in gender medicine.